Host-Parasite Immune Interactions

Course leader: Dr Iva Kolarova
Home Institution: Charles University, Prague, Czech Republic

Course pre-requisite(s): Basic Parasitology and Basic Immunology are recommended

 

Course Overview
The aim of the course is to provide information about host-parasite immune interactions, in particular about human immune mechanisms operating against parasites, parasite escape mechanism, immunopathology of parasitic infections, serodiagnostic techniques, and anti-parasite vaccine development.

Learning Outcomes:

By the end of the course students should be able to understand basic principles in the mammalian host immune reaction against different protozoan parasites and ectoparasites. They should identify the similarities and differences in host defence mechanisms based on the parasite location (intracellular or extracellular) (blood, tissue, or lumen). Students should be able to explain the difficulties in developing a vaccine against parasites.

Course Content:

Topics covered in the course include leishmaniases, trypanosomiases (T. cruzi, T. brucei), toxoplasmosis, giardiasis, cryptosporidiosis, malaria, bloodsucking insect vectors, and ticks. Additional topics to be addressed are vaccine development and utilization of host immune response in diagnosis. This course does not cover helminthic infections and direct diagnostic methods.

Instructional Method:

This course is based on lectures (powerpoint presentations, including videos).

Assessment:

The final exam is a quiz containing a mixture of multiple-choice and free-response questions. Students’ progress during the course will be evaluated using short quizzes (5-10 minutes) and discussions during lectures.